I have had both the LMS Meth kit and the HPFP setup to run E30(which is what I currently run). Here is my take on the two options...
With LMS the meth kit has always been a solution to offset the lack of available fuel with the stock setup. The by product of cooling the charge is where you see the extra power. Point in case, LMS will not tune your vehicle to be dependent on methanol. I have datalogs and information showing what happens when you turn off meth the LMS tunes, and its perfectly safe at least on their 2010-2012 tunes. People have seen a few tenths off the 1/4 mile times just by cooling the MCT's significantly. The negatives with the kit is you are adding an ADDITIONAL pump to maintain, adding another reservoir to house methanol, and the installation is significantly more involved than installing a HPFP. Additionally the standard settings are OK at best, but to really optimized the kit, you will need to tune the methanol controller for the tune you are running which would be the ramp, initialization, and gain of the methanol controller. That said, a lot of people have success with the standard settings.
Any tuner will tune for the LMS Alky Control kit, and with basic bolt ons, and an aggressive meth dependent tune, low 12's are achievable, however, you will be dependent on methanol to increase fueling and octane. If something happens in the middle of the run, there is a good chance of damage. However, very few people have had that happen.
For the E30 tunes with a HPFP its MUCH easier to maintain, install, and keep running. The install for the Firestorm Pump or any HPFP is about 10 minutes.. I have a detailed write up on how to do it on the EBPF. Mixing in E85 to get E30 with 93 pump has proven to really REALLY be an effective fueling solution coupled with the HPFP. If you purchase the GH intercooler with it, then you get significant IAT drops that is ALMOST as good as what meth is able to provide with the stock IC. There are people running high 11's with a good E30 tune. I know some of GH's customers are seeing over 500tq/500hp at the wheels with the above setup. There is nothing to really maintain with this setup and its just making sure you are fueling correctly. This is why I have gone the route of E30 as its just soo much easier and I don't need to worry about an issue with the meth pump or lines. Its pretty much a set and forget solution. However, it does cost quite a bite more to go this route... Meth Kit is about $1K (and I would ONLY get the Alky Controls kit as it has been proven time and time again to have less issues than others) where as the Pump and IC together are gonna run you around $2400 but you get a set and forget solution that thus far is producing better results.
Tomorrow I am going to be putting my car on a dynojet to run the GH E30 Tune and the LMS Custom E30 tune I have to see where they are.