Kirk is leaving at 4 am Sat, running straight through for a 9 pm arrival, a beef samich, a beer then bed.
Tim, It all depends on what day and time of day.
Option 1 avoid the most traffic, take 80 west past Chicago then 355 North to Schaumburg/Elk Grove Area exit Higgins head east = most miles least sitting still if any.
Option 2 my preferred way 80 to 294 north to 90 west going around east and north side of O'Hare Airport, exit Elmhurst road south and 5 min from hotel.
Option 3 Best if after 7pm through 6 am. 80 to 94 North right through the heart of downtown (Milwaukee) then split west on 90 toward Rockford/O'Hare and exit Elmhurst rd south, 2nd exit past O'Hare.
#3 is Kirks route, doesn't mind a little traffic and you can look at the Skyline, just don't break down, wreck or run out of gas.
Be logical, I cant predict every event Cubs/Sox/Taste of Chicago/Blues fest/accident that can screw any of these up. Just stay in the left lane and keep up and you will be fine.