To make sure I get the 300,000+ mile SHO to and from the beach that is 545 miles away each year (usually about 1,200 miles round trip), I load her up with the wife and two young daughters, beach gear, two windsurfers, three sails, a boom, a mast and most importantly, the GPS receiver. If I have to worry about something failing during my trip then I haven't been taking very good care of my pride and joy.
If you properly maintain the car, there is no reason it cannot take you anywhere you want to go. The key word there is "properly."
You can't wait until things break or scream out for attention and expect the car to keep going. You have to be attentive to the unusual noises or different feelings in the engine, suspension or transmission to proactively service the parts before they fail catastrophically and damage things that didn't break on their own.
Leaks, drips, smells, low fluids, odd noises, vibrations, moans, squeaks, rattles, high efforts, uneven wear.... The list goes on, but those are all things that you should take as warnings that something is not as it should be. Those things are the car calling out to you to spend some detailed time taking care of what needs attention.
Any car that gets to be 147,000+ miles old needs your tender loving mechanical care to be a dependable road warrior. Maintain it and she will roll. May you have a safe and uneventful trip.