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I have 4.5" MTX's in the front doors. 6x8" MTX's in the rear deck. I have a 12" Champion Pioneer Sub. One 4x60 Pioneer amp. Then I have a 400watt peak Pioneer amp. Also I have the Kenwood KDC-32 faceplate
It's been a long time since I removed my stock speakers but I believe the fronts were 6.5. I always had either a 6.5 component or 5x7 speaker in the front. 4.5 just seems kind of small for a front speaker.
6.5s in the front doors fit very easily and are a nice upgrade. The rear speakers depended on what year car you have. My 91+ came with 5x7s mounted up top and 6x9s mounted underneath. I replaced both with good quality 6x9s. I have a full Alpine system.